FARGO — Nancy Saeger’s battle with depression became official with her diagnosis of major depressive disorder more than 30 years ago. Looking back, however, she believes depression has been a dark cloud over most of her life.

“I’ve spent a lot of time crying,” Saeger said. “Fortunately, I’ve never had suicidal ideation.”

A succession of antidepressants offered only partial relief, and she would soon have to rotate to a new drug. She has what her psychiatrist calls treatment-resistant depression.

About the only conventional treatment she hadn’t tried was electroconvulsive therapy, electrical stimulation of the brain while under anesthesia, which can cause memory loss. That’s not something she wants to risk.

Then, more than a year and a half ago, a friend told her that her son had found relief from his chronic pain and depression with a drug called ketamine.

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